Intake of fruit and leaves of sweet cherry beneficially affects lipid metabolism, oxidative stress and inflammation in Wistar rats fed with high fat-cholesterol diet

Kinga Dziadek , Aneta Kopeć , Ewa Piątkowska


The aim of this study was to assess the effect of an addition of sweet cherry fruit or leaves (unexplored until now) to high fat-cholesterol (HFC) diet on selected biochemical parameters and expression of genes involved in fatty acid metabolism in male Wistar rats. The addition of sweet cherry fruit and leaves to HFC diet resulted in decrease in body gain, improvement of the liver function as well as reduction of oxidative stress and inflammation. Additionally, fruit and leaves had a beneficial impact on lipid metabolism, thereby reducing lipid accumulation in liver and improving lipid profile in the serum. These effects result from the regulation of expression of fatty acid synthesis and oxidation-related genes. It can be summarized that not only fruit of sweet cherry but also leaves, may have a potential application in the fight against non-communicable diseases, especially obesity and cardiovascular diseases.
Author Kinga Dziadek (FoFT / DoHN)
Kinga Dziadek,,
- Department of Human Nutrition
, Aneta Kopeć (FoFT / DoHN)
Aneta Kopeć,,
- Department of Human Nutrition
, Ewa Piątkowska (FoFT / DoHN)
Ewa Piątkowska,,
- Department of Human Nutrition
Journal seriesJournal of Functional Foods, ISSN 1756-4646, (N/A 100 pkt)
Issue year2019
Publication size in sheets0.5
Keywords in EnglishSweet cherry fruit, sweet cherry leaves, High fat-cholesterol diet, Lipid metabolism genes, Antioxidant enzymes, Inflammation markers
ASJC Classification2701 Medicine (miscellaneous); 2916 Nutrition and Dietetics; 1106 Food Science
Internal identifierWTŻ/2019/35
Languageen angielski
Score (nominal)100
Score sourcejournalList
Publication indicators WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.217; WoS Impact Factor: 2018 = 3.197 (2) - 2018=3.833 (5)
Citation count*3 (2020-03-28)
Additional fields
FinansowanieThis study was financed by the National Science Centre, Poland (Grant no. 2015/17/N/NZ9/01136).
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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