A Novel System for Patient Ventilation and Dosing of Hyperpolarized 3He for Magnetic Resonance Imaging of Human Lungs

Robert Kordulasiński , Marta Królewska , Bartosz Głowacz , Lutosława Mikowska , Zbigniew Olejniczak , Tadeusz Pałasz , Mateusz Suchanek , Winicjusz Filipow , Tomasz Dohnalik

Abstract

A versatile ventilator for controlling a patient’s breath cycle and dosing 3He gas has been designed and constructed. It is compatible with a medical magnetic resonance imaging scanner and can be incorporated into routine human lungs imaging procedure that employs hyperpolarized noble gas as a contrast agent. The system adapts to the patient’s lung volume and their breath cycle rhythm, providing maximum achievable comfort during the medical examination. Good quality magnetic resonance lung images of healthy volunteers were obtained. The system has the capability of recycling the exhaled gas to recover the expensive 3He isotope, and can be also adapted to human lung imaging with hyperpolarized 129Xe.
Author Robert Kordulasiński - TransCom International
Robert Kordulasiński,,
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, Marta Królewska - TransCom International
Marta Królewska,,
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, Bartosz Głowacz - Jagiellonian University (UJ)
Bartosz Głowacz,,
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, Lutosława Mikowska - Jagiellonian University (UJ)
Lutosława Mikowska,,
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, Zbigniew Olejniczak - Jagiellonian University (UJ)
Zbigniew Olejniczak,,
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, Tadeusz Pałasz - Uniwersytet Jagielloński
Tadeusz Pałasz,,
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, Mateusz Suchanek (FoAaE / DoSaA)
Mateusz Suchanek,,
- Department of Soil Science and Agrophysics
, Winicjusz Filipow - TransCom International
Winicjusz Filipow,,
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, Tomasz Dohnalik - Jagiellonian University (UJ)
Tomasz Dohnalik,,
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Journal seriesApplied Sciences-Basel, [Applied Sciences (Switzerland)], ISSN 2076-3417, (N/A 70 pkt)
Issue year2020
Vol10
No9
Pages1-11
Publication size in sheets0.5
Keywords in English3He; 129Xe; HP gas; ventilator; MRI; lung
ASJC Classification1507 Fluid Flow and Transfer Processes; 1508 Process Chemistry and Technology; 1706 Computer Science Applications; 2200 General Engineering; 2500 General Materials Science; 3105 Instrumentation
DOIDOI:10.3390/app10093163
URL https://www.mdpi.com/2076-3417/10/9/3163
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
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A Novel System for Patient Ventilation and Dosing of Hyperpolarized 3He for Magnetic Resonance Imaging of Human Lungs of 18-06-2020
2,21 MB
Score (nominal)70
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.985; WoS Impact Factor: 2018 = 2.217 (2) - 2018=2.287 (5)
Citation count*
Additional fields
LicencjaThis research was funded by the Polish National Center for Research and Development within the PBS program, edition 3, number PBS3/A9/35/2015.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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