The expression profile of genes involved in osteoclastogenesis detected in whole blood of Arabian horses during 3 years of competing at race track

Monika Stefaniuk-Szmukier , Katarzyna Ropka-Molik , Katarzyna Piórkowska , Monika Bugno-Poniewierska

Abstract

One of the most significant reason of economic loss on race track performance is lame in performed horses. Primarily, due to the failure within proper bone maintenance during conditioning in young horses. The training overload causes bone turnover disturbances in homeostasis between bone resorption and bone formation which promote the bone loss. Within our study we investigated training induced changes in transcript abundance of genes (NFATc1, CTSK, DAP12, CLEC5A, IL6ST, VAV3) involved in osteoclastogenesis hence bone resorption, in whole blood of Arabian horses. The expression pattern of all analysed genes varied depend of exercise intense activity. All training stages generate similar response to training whatever season was. The initial training had greater effect on expression pattern than increased, prolonged, established conditioning. Notwithstanding, the significant increase of transcript abundance of all investigated genes was observed during period of starts with racing competition. There is no biomarker known with highly significant accuracy according to degree of articular cartilage or bone disease in a single joint. Thus, the markers presented in our report, poses the potential to be further investigate as useful tool for bone turnover.
Author Monika Stefaniuk-Szmukier (FoAS / IoAS)
Monika Stefaniuk-Szmukier,,
- Institute of Animal Science
, Katarzyna Ropka-Molik
Katarzyna Ropka-Molik,,
-
, Katarzyna Piórkowska
Katarzyna Piórkowska,,
-
, Monika Bugno-Poniewierska (FoAS / IoVS)
Monika Bugno-Poniewierska,,
- Institute of Veterinary Sciences
Journal seriesResearch in Veterinary Science, ISSN 0034-5288, e-ISSN 1532-2661, (N/A 100 pkt)
Issue year2019
Vol123
Pages59-64
Publication size in sheets0.5
Keywords in EnglishArabian horses, Racing training, Bone remodelling, Gene expression, Osteoclastogensis
ASJC Classification3400 General Veterinary
DOIDOI:10.1016/j.rvsc.2018.12.013
URL https://www.sciencedirect.com/science/article/pii/S0034528818311676?via%3Dihub
Internal identifierWHiBZ/2019/2
Languageen angielski
Score (nominal)100
Score sourcejournalList
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.941; WoS Impact Factor: 2018 = 1.751 (2) - 2018=1.762 (5)
Citation count*
Additional fields
FinansowanieThe study was supported by the National Science Centre (project no. 2014/15/D/NZ9/05256)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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