Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses

Michał Dziadek , Timothy E.L. Douglas , Kinga Dziadek , Barbara Zagrajczuk , Andrada Serafim , Izabela-Cristina Stancu , Katarzyna Cholewa-Kowalska


In this work, for the first time, a material derived from food industry waste – whey protein isolate – and a material commonly used in bone regeneration – bioactive glasses – were combined to obtain novel composite biomaterials with potential applications in bone tissue engineering (BTE). Additionally, to obtain pro-angiogenic properties, sol–gel-derived BGs doped with Cu2+ and Co2+ ions were used. Using a simple gas foaming method, ready-to-use (sterile), bioactive scaffolds with high porosity (above 70%), fully connected pore networks, and pore size suitable for BTE applications (80–350 μm) were obtained. Furthermore, scaffolds showed additional functionalities – calcium phosphate-forming ability and gradual release of therapeutic ions. Porous WPI/BG composites showed great potential for use as novel bone substitutes.
Author Michał Dziadek - Jagiellonian University (UJ)
Michał Dziadek,,
, Timothy E.L. Douglas - Lancaster University, United Kingdom
Timothy E.L. Douglas,,
, Kinga Dziadek (FoFT / DoHN)
Kinga Dziadek,,
- Department of Human Nutrition
, Barbara Zagrajczuk - University of Science and Technology (AGH)
Barbara Zagrajczuk,,
, Andrada Serafim - University Politehnica of Bucharest, Romania
Andrada Serafim,,
, Izabela-Cristina Stancu - University Politehnica of Bucharest, Romania
Izabela-Cristina Stancu,,
, Katarzyna Cholewa-Kowalska - University of Science and Technology (AGH)
Katarzyna Cholewa-Kowalska,,
Journal seriesMaterials Letters, ISSN 0167-577X, e-ISSN 1873-4979, (N/A 70 pkt)
Issue year2020
Publication size in sheets0.5
Article number127115
Keywords in EnglishGas foaming, Bone tissue engineering, Waste material, Micro-computed tomography
ASJC Classification2210 Mechanical Engineering; 2211 Mechanics of Materials; 2500 General Materials Science; 3104 Condensed Matter Physics
Languageen angielski
Score (nominal)70
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.887; WoS Impact Factor: 2018 = 3.019 (2) - 2018=2.624 (5)
Citation count*2 (2020-08-07)
Additional fields
FinansowanieThis work was supported by the National Science Centre, PolandGrant No. 2019/32/C/ST5/00386 (MD). MD acknowledges financialsupport from the Foundation for Polish Science (FNP). TD acknowl-edges N8 network (Food2Bone grant). ThemCT investigation waspossible due to the financial support of the European RegionalDevelopment Fund(6695072), through Competitiveness Opera-tional Program 2014-2020, Priority axis 1, ID P_36_611, MySMIScode 107066, INOVABIOMED, Romania.
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