Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle

Joanna Pokorska , A. Piestrzynska-Kajtoch , Dominika Kułaj , Andrzej Ochrem , Anna Radko

Abstract

Background Mastitis is one of the most serious diseases of dairy cattle, causing substantial financial losses. While predisposition to reduced somatic cell count in milk has been considered for in cattle breeding programs as the key indicator of udder health status, scientists are seeking genetic markers of innate immune response, which could be helpful in selecting cows with improved immunity to mastitis. Lipocalin-2 (LCN2) is a protein involved in the response of the immune system by eliminating iron ions which are necessary for the growth of pathogenic bacteria, so LCN2 may be considered as a natural bacteriostatic agent and could become a marker of infection. Results A total of five SNPs were identified in LCN2 gene (one in the promoter, three in exon 1, and one in intron 1). A single haplotype block was identified. The locus g.98793763G > C was found to have a significant impact on protein levels in milk, and alleles of this locus were identified to have a significant positive dominance effect on this trait. None of the four analysed loci had a statistically significant impact on the milk yield, fat levels in milk or the somatic cell score. LCN-2 gene had no significant impact on the incidence of mastitis in the cows. Conclusions Although the identified SNPs were not found to have any impact on the somatic cell count or the incidence of mastitis in cows, it seems that further research is necessary, covering a larger population of cattle, to confirm the association between lipocalin-2 and milk production traits and mastitis.
Author Joanna Pokorska (FoAS / IoAS)
Joanna Pokorska,,
- Institute of Animal Science
, A. Piestrzynska-Kajtoch
A. Piestrzynska-Kajtoch,,
-
, Dominika Kułaj (FoAS / IoAS)
Dominika Kułaj,,
- Institute of Animal Science
, Andrzej Ochrem (FoAS / IoAS)
Andrzej Ochrem,,
- Institute of Animal Science
, Anna Radko
Anna Radko,,
-
Journal seriesElectronic Journal of Biotechnology, ISSN 0717-3458, (N/A 70 pkt)
Issue year2019
Vol40
Pages17-21
Publication size in sheets0.5
Keywords in EnglishAlleles, Breeding, Cattle, Gene polymorphism, Haplotype, Lipocalin-2 Mastitis, Milk, SNP, Somatic cell score, Udder
ASJC Classification1305 Biotechnology; 2402 Applied Microbiology and Biotechnology
DOIDOI:10.1016/j.ejbt.2019.04.004
URL https://reader.elsevier.com/reader/sd/pii/S071734581930020X?token=7FFF1F5C42A0B145CB60277E2396DE0BE8269C1AEB1E1F35F0AE9DDB99DA3E45DE906D5E5B401EF3E6A83437A9343A41
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa - Użycie Niekomercyjne - Bez utworów zależnych (CC-BY-NC-ND); after publication
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Polymorphism of bovine lipocalin-2 gene and its impact on milk production traits and mastitis in Holstein Friesian cattle of 20-09-2019
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Score (nominal)70
Score sourcejournalList
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.127; WoS Impact Factor: 2018 = 2.04 (2) - 2018=2.122 (5)
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FinansowanieThe study was financial supported from the Ministry of Science and Higher Education in Poland (DS 3259/2017)
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