The influence of sGnRH-A and antidopaminergic drug - pimozide - on prolactin mRNA synthesis in female Prussian carp (Carassius gibelin Bloch) in vivo. Czech Journal of Animal Science

Jarosław Chyb , Magdalena Socha , Paweł Szczerbik , Mirosław Sokołowska-Mikołajczyk , T. Mikołajczyk , Piotr Epler

Abstract

Effects of salmon gonadotropin releasing hormone analogue (sGnRH-A) and antidopaminergic drug, pimozide, on the synthesis of prolactin mRNA in vivo in female Prussian carp (Carassius gibelio Bloch) during two different stages of the reproductive cycle were evaluated. The results showed that the lowest dose of sGnRH-A (5 μg/kg body weight) significantly stimulated the mRNA synthesis in fish during the recrudescence as well as during the preovulatory period, higher doses of this compound having no significant effect on prolactin mRNA synthesis. The blocker of dopamine receptors, pimozide, also potentiated prolactin mRNA synthesis – in recrudescent females it increased mRNA levels at the dose of 1 mg/kg, while in the preovulatory period all of the used pimozide doses (1, 5, and 10 mg/kg) were responsible for the increase of prolactin mRNA levels. Taken together, the above results suggest that gonadotropin releasing hormone (GnRH) is the factor responsible for the stimulation of prolactin synthesis, while dopamine has an inhibitory influence on the prolactin production.
Author Jarosław Chyb (DoAS / DoIaF)
Jarosław Chyb,,
- Department of Ichthyobiology and Fisheries
, Magdalena Socha (DoAS / DoIaF)
Magdalena Socha,,
- Department of Ichthyobiology and Fisheries
, Paweł Szczerbik (DoAS / DoIaF)
Paweł Szczerbik,,
- Department of Ichthyobiology and Fisheries
, Mirosław Sokołowska-Mikołajczyk (DoAS / DoIaF)
Mirosław Sokołowska-Mikołajczyk,,
- Department of Ichthyobiology and Fisheries
, T. Mikołajczyk
T. Mikołajczyk,,
-
, Piotr Epler (DoAS / DoIaF)
Piotr Epler,,
- Department of Ichthyobiology and Fisheries
Journal seriesCzech Journal of Animal Science, ISSN 1212-1819, (A 30 pkt)
Issue year2013
Vol58
No1
Pages31-36
Publication size in sheets0.5
Keywords in EnglishPRL, gonadotropin releasing hormone, dopamine, fish, mRNA synthesis, pituitary
ASJC Classification1103 Animal Science and Zoology
URL http://agriculturejournals.cz/publicFiles/82104.pdf
Internal identifierWHiBZ/2013/42
Languageen angielski
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The influence of sGnRH-A and antidopaminergic drug - pimozide - on prolactin mRNA synthesis in female Prussian carp (Carassius gibelin Bloch) in vivo. Czech Journal of Animal Science 267,68 KB
Score (nominal)30
Score sourcejournalList
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 0.87; WoS Impact Factor: 2013 = 0.871 (2) - 2013=0.857 (5)
Citation count*
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FinansowanieSupported by the Polish Ministry of Science and Higher Education (Grant No. N N303 2750 33)
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