The influence of sGnRH-A and antidopaminergic drug - pimozide - on prolactin mRNA synthesis in female Prussian carp (Carassius gibelin Bloch) in vivo. Czech Journal of Animal Science
Jarosław Chyb , Magdalena Socha , Paweł Szczerbik , Mirosław Sokołowska-Mikołajczyk , T. Mikołajczyk , Piotr Epler
AbstractEffects of salmon gonadotropin releasing hormone analogue (sGnRH-A) and antidopaminergic drug, pimozide, on the synthesis of prolactin mRNA in vivo in female Prussian carp (Carassius gibelio Bloch) during two different stages of the reproductive cycle were evaluated. The results showed that the lowest dose of sGnRH-A (5 μg/kg body weight) significantly stimulated the mRNA synthesis in fish during the recrudescence as well as during the preovulatory period, higher doses of this compound having no significant effect on prolactin mRNA synthesis. The blocker of dopamine receptors, pimozide, also potentiated prolactin mRNA synthesis – in recrudescent females it increased mRNA levels at the dose of 1 mg/kg, while in the preovulatory period all of the used pimozide doses (1, 5, and 10 mg/kg) were responsible for the increase of prolactin mRNA levels. Taken together, the above results suggest that gonadotropin releasing hormone (GnRH) is the factor responsible for the stimulation of prolactin synthesis, while dopamine has an inhibitory influence on the prolactin production.
|Journal series||Czech Journal of Animal Science, ISSN 1212-1819, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||PRL, gonadotropin releasing hormone, dopamine, fish, mRNA synthesis, pituitary|
|Publication indicators||= 0; : 2013 = 0.87; : 2013 = 0.871 (2) - 2013=0.857 (5)|
|Finansowanie||Supported by the Polish Ministry of Science and Higher Education (Grant No. N N303 2750 33)|
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