Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle

Artur Gurgul , Igor Jasielczuk , E. Semik-Gurgul , Tomasz Szmatoła , Anna Majewska , Ewa Sosin-Bzducha , Monika Bugno-Poniewierska

Abstract

Polish Red cattle is one of the few indigenous breeds of European red cattle which is characterized by several desired features, such as high disease resistance, good health, longevity, good fertility, and high nutritional value of milk. Currently, Polish Red cattle population is a subject of two independent breeding programs: (i) improvement program and (ii) genetic resources conservation program. The aim of the improvement program is the genetic progress in terms of milk production and body conformation traits, while the conservation program mainly focuses on protection of the genetic resources of Polish Red cattle and preservation of the existing, original gene pool. By the analysis of FST genetic distances across genome-wide SNP panel, we detected diversifying selection signatures among these two subpopulations and indicated (among others) the significance of DGAT1 and FGF2 genes for milk production traits in these cattle. We also found that among genes being presumably under selection in terms of milk production, there are genes responsible, for example, for mammary gland development (e.g., SOSTDC1, PYGO2, MED1, and CCND1) and immune system response (e.g., IL10RA, IL12B, and IL21). The most important finding of this study is that the most pronounced genetic differences between the analyzed populations were associated with β-defensin genes (e.g., DEFB1, DEFB4A, DEFB5, DEFB7, DEFB10, DEFB13, EBD, BNBD-6, and LAP) located within so-called bovine cluster D on BTA27. The β-defensins are expressed mainly in the mammary gland and are antimicrobial peptides against the Gram-negative and Gram-positive bacteria, viruses, and other unicellular parasites. This suggests that antimicrobial resistance of mammary gland is of high importance during selection towards increased milk production and that genes responsible for this process are selected together with increasing levels of productivity.
Author Artur Gurgul
Artur Gurgul,,
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, Igor Jasielczuk
Igor Jasielczuk,,
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, E. Semik-Gurgul
E. Semik-Gurgul,,
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, Tomasz Szmatoła
Tomasz Szmatoła,,
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, Anna Majewska
Anna Majewska,,
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, Ewa Sosin-Bzducha
Ewa Sosin-Bzducha,,
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, Monika Bugno-Poniewierska (FoAS / IoVS)
Monika Bugno-Poniewierska,,
- Institute of Veterinary Sciences
Journal seriesJournal of Applied Genetics, ISSN 1234-1983, e-ISSN 2190-3883, (N/A 100 pkt)
Issue year2019
Vol60
No1
Pages87-95
Publication size in sheets0.5
Keywords in Englishβ-Defensins, Milk production, Polish Red cattle, Selection signatures
ASJC Classification2700 General Medicine; 1311 Genetics
DOIDOI:10.1007/s13353-019-00484-0
URL https://link.springer.com/content/pdf/10.1007%2Fs13353-019-00484-0.pdf
Internal identifierWHiBZ/2019/4
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
Score (nominal)100
Score sourcejournalList
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.689; WoS Impact Factor: 2018 = 1.725 (2) - 2018=1.973 (5)
Citation count*
Additional fields
FinansowanieThe study was financed from funds of the project: "Directions for use and conservation of livestosk genetic resources in sustainable development" co-financed by the National Research and Development Center (Poland) under the Strategic Research and Development Program: "Environment, Agriculture and Forestry" - BIOSTRATEG, the decision number BIOSTRATEG2/297267/14/NCBR/2016.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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