Expression of serotonin, somatostatin, and glucagon-like peptide 1 (GLP1) in the intestinal neuroendocrine cells of pigs fed with population rye type and hybrid rye type grains

Anna Zacharko-Siembida , Marcin B. Arciszewski , Jose Luis Valverde Piedra , Ewa Tomaszewska , Sylwia Szymańczyk , Siemowit Muszyński , Piotr Dobrowolski , Sylwia Mozel , Tomasz Schwarz

Abstract

Neuroendocrine cells (NEC) are a cell population in the gastrointestinal tract that plays a role in the regulation of the digestion process, satiety and nutrient homeostasis. NE cells express a variety of bioactive hormones that can undergo changes in response to different luminal stimuli, including multiple components, which are present in the diet. In recent years, a modern (hybrid) type of rye grain has been introduced to feed industry. The goal of the present study was to determine immunohistochemically whether the feeding of the pigs with population and hybrid rye grains may evoke adverse changes in the small and large intestines in terms of the expression of serotonin, glucagon-like peptide 1 (GLP1) and somatostatin. Feeding animals with population and hybrid rye grains resulted in a slight increase in serotonin-positive NE cells in the small intestine (but not in the large intestine). After feeding animals with population rye (but not with hybrid rye) grains, there was a decrease in the small intestine GLP1-immunoreactive NE cells was found. No changes in the expression of GLP1 were found in the large intestine of experimental animals. The numbers of somatostatin-IR NEC in the small and large intestines were not affected by feeding with either population or hybrid rye grains. In conclusion, we found that feeding pigs with hybrid and population rye grains started adaptive changes in NEC. However, those changes were not profound, which allows us to speculate that adverse effects of these rye grains have a minor (if any) impact on the gut hormone balance (and indirectly on the health status) of animals.
Author Anna Zacharko-Siembida
Anna Zacharko-Siembida,,
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, Marcin B. Arciszewski
Marcin B. Arciszewski,,
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, Jose Luis Valverde Piedra
Jose Luis Valverde Piedra,,
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, Ewa Tomaszewska
Ewa Tomaszewska,,
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, Sylwia Szymańczyk
Sylwia Szymańczyk,,
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, Siemowit Muszyński
Siemowit Muszyński,,
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, Piotr Dobrowolski
Piotr Dobrowolski,,
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, Sylwia Mozel
Sylwia Mozel,,
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, Tomasz Schwarz (FoAS / DoSaSRB)
Tomasz Schwarz,,
- Department of Swine and Small Ruminant Breeding
Journal seriesMedycyna Weterynaryjna, [Medycyna Weterynaryjna], ISSN 0025-8628, (N/A 20 pkt)
Issue year2019
No75 (10)
Pages593-598
Publication size in sheets0.5
Keywords in Englishrye, grain, feeding, farm animals, neuroendocrine cells, gastrointestinal tract
ASJC Classification3400 General Veterinary
DOIDOI:10.21521/mw.6251
URL http://www.medycynawet.edu.pl/archives/423/6251-summary-med-weter-75-05-6251-2019
Languageen angielski
Score (nominal)20
Score sourcejournalList
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.25; WoS Impact Factor: 2018 = 0.28 (2) - 2018=0.257 (5)
Citation count*
Additional fields
Finansownaie The study was financed by the National Centre for Research and Development, Poland, under the BIOSTRATEG 2/297910/12/NCBR/2016, ENERGYFEED research project.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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