Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats
Joanna Tkaczewska , Barbara Borczak , Ewa Piątkowska , Joanna Kapusta-Duch , Małgorzata Morawska , Tomasz Czech
AbstractCarp skin gelatine hydrolysates can be a potential source of bioactive peptides with strong antioxidant properties tested in vitro, but there is no information on in vivo activity. Therefore, the objective of this study was to determine the ability of an antioxidant carp skin gelatine hydrolysate to attenuate plasma/serum levels of some oxidative stress markers in healthy adult Wistar rats. Analysis of hydrolysate included safety in an animal organism (haematological blood parameters, CRP, hepatic and kidney function), biological value (BV, TD, NPU), evaluation of the lipid profile (TC, LDL-C, HDL-C, TAG) and antioxidant blood status (TAS, MDA, GSR, HO-1). The results indicate that fish protein hydrolysates are safe for laboratory animals, but have very low biological value. An increase in glutathione reductase activity in the blood serum of healthy animals fed with carp skin gelatine hydrolysate supplements is a promising indicator of its antioxidant in vivo properties.
|Journal series||Journal of Functional Foods, ISSN 1756-4646, (N/A 100 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Carp Gelatine Antioxidant activity Bioactive peptide In vivo study|
|ASJC Classification||; ;|
|Publication indicators||= 1; : 2018 = 1.217; : 2018 = 3.197 (2) - 2018=3.833 (5)|
|Citation count*||1 (2020-03-27)|
|Finansowanie||This work was supported by the National Centre for Research and Development, Poland [Grant No: Lider/21/0003/1-7/15/NCBR/2016]|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.