Tulathromycin enhances humoral but not cellular immune response in pigs vaccinated against swine influenza

Małgorzata Pomorska-Mól , Krzysztof Kwit , Ewelina Czyżewska-Dors , Zygmunt Pejsak

Abstract

The effect of a standard, single dose therapy with tulathromycin was investigated on the postvaccinal humoral and cellular immune response in pigs vaccinated against swine influenza. Forty‐five pigs, divided into 3 groups, were used (control not vaccinated (C, n = 15), control vaccinated (CV, n = 15), and experimentally received tulathromycin (TUL, n = 15)). For vaccination of pigs, an inactivated, commercial vaccine was used. Pigs from TUL group received single dose of tulathromycin intramuscularly, at the recommended dose (2.5 mg/kg body weight). Pigs from TUL and CV groups were vaccinated at 8 and 10 weeks of age. The specific humoral and cellular immune response against swine influenza virus (SIV) was evaluated. The results of present study showed that humoral postvaccinal response after vaccination against SIV can be modulated by treatment with tulathromycin. In pigs from TUL group, the significantly higher titers of anti‐SIV‐specific antibodies were observed 4 and 6 weeks after booster dose of vaccine. Simultaneously, T‐cell‐mediated immune response against SIV was not affected by tulathromycin. Our recent study confirmed the importance of defining the modulatory activity of tulathromycin because of its influence on the immune response to vaccines. Since the antibodies against hemagglutinin are crucial for the protection against SIV, the present observations should prompt further studies on the practical significance of recent results in terms of clinical implications (postvaccinal protection) in the field conditions.
Author Małgorzata Pomorska-Mól
Małgorzata Pomorska-Mól,,
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, Krzysztof Kwit
Krzysztof Kwit,,
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, Ewelina Czyżewska-Dors
Ewelina Czyżewska-Dors,,
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, Zygmunt Pejsak (VET)
Zygmunt Pejsak,,
- University Centre for Veterinary Medicine UJ-UR
Journal seriesJournal of Veterinary Pharmacology and Therapeutics, ISSN 0140-7783, e-ISSN 1365-2885, (N/A 70 pkt)
Issue year2019
Vol42
No3
Pages318-323
Publication size in sheets0.5
Keywords in Englishimmune response, pigs, swine influenza, tulathromycin, vaccination
ASJC Classification3400 General Veterinary; 3004 Pharmacology
DOIDOI:10.1111/jvp.12742
URL https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvp.12742
Languageen angielski
Score (nominal)70
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.861; WoS Impact Factor: 2018 = 1.175 (2) - 2018=1.397 (5)
Citation count*
Additional fields
FinansowanieThe National Science Centre, Grant/Award Number: DEC-2012/05/B/NZ7/03114
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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