Genetic screening for cerebellar abiotrophy, severe combined immunodeficiency and lavender foal syndrome in Arabian horses in Poland
Monika Bugno-Poniewierska , Monika Stefaniuk-Szmukier , Agata Piestrzynska-Kajtoch , Agnieszka Fornal , Katarzyna Piórkowska , Katarzyna Ropka-Molik
AbstractThe highly selective breeding of Arabian horses results in inbreeding depression and genetic disorders, thereby causing significant economic loss. The Polish population of Arabians has a great impact on many breeding programmes. The aim of the current study was to monitor genetic variants involved in the most common genetic disorders of this breed. A total of 808 elite Arabian horses were screened for cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID) and lavender foal syndrome (LFS) genetic disorders by Sanger sequencing and allelic discrimination methods. The investigated population was clear of LFS. The unfavourable SCID allele was detected in three heterozygous horses (q = 0.00185). Regarding CA, the minor allele frequency was q = 0.04029. This is the first report of SCID carriers in Poland. This investigation demonstrates the value of genetic testing to support breeding decisions and to facilitate genetic disease monitoring.
|Journal series||Veterinary Journal, ISSN 1090-0233, e-ISSN 1532-2971, (N/A 140 pkt)|
|Publication size in sheets||0.3|
|Keywords in English||Arabian horses, Cerebellar abiotrophy, Genetic testing, Lavender foal syndrome, Severe combined immunodeficiency|
|Publication indicators||= 3; : 2016 = 1.138; : 2019 = 2.115 (2) - 2019=2.268 (5)|
|Finansowanie||The study was financed by the National Research and Development Center (Poland) BIOSTRATEG2/297267/14/NCBR/2016.|
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