Animals in Iodine Deficiency or Sulfadimethoxine Models of Thyroid Damage Are Differently Affected by the Consumption of Brassica Sprouts

Paweł Paśko , Ewelina Prochownik , Mirosław Krośniak , Małgorzata Tyszka-Czochara , Renata Francik , Monika Marcinkowska , Jakub Sikora , Mateusz Malinowski , Paweł Zagrodzki

Abstract

The study was primarily aimed at investigating the effect of brassica sprout consumption, namely rutabaga (Brassica napus L. var. napobrassica) sprouts (R) generally recognized as antithyroid agent due to its goitrogenic substance content, on hematological, biochemical, and immunological parameters in rats. Sprouts were tested alone and in a combination with other antithyroid factors, such as iodine deficiency (RDI) and sulfadimethoxine (RS). The expression of the heme oxygenase-1 (HO-1) gene in the thyroid as a stress-inducible protein was determined. The thermographic analysis was also estimated. The intake of rutabaga sprouts by healthy rats did not reveal any significant, harmful effect on the thyroid function. Both body temperature and expression of HO-1 remained unchanged in response to the consumed sprouts. In animals with hypothyroidism, rutabaga sprouts enhanced the negative effect of iodine deficiency or sulfadimethoxine ingestion on the organism by increasing the WBC (RDI), TNF-α (RS), creatinine (RS), and triglyceride (RDI and RS) levels, as well as decreasing PLT (RS) level. Moreover, rutabaga sprout consumption by rats with iodine deficiency and sulfadimethoxine decreased their body temperature. Additionally, the concomitant administration of sprouts and iodine depletion significantly reduced the expression of HO-1 in the thyroid. The results may prove useful in confirming rutabaga sprout consumption to be safe, though the seeds of this vegetable provide a well-known antithyroid agent. Our results have shown that rutabaga sprout consumption may be also a factor that enhances the negative clinical features only when combined with iodine deficiency and sulfadimethoxine ingestion.
Author Paweł Paśko
Paweł Paśko,,
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, Ewelina Prochownik
Ewelina Prochownik,,
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, Mirosław Krośniak
Mirosław Krośniak,,
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, Małgorzata Tyszka-Czochara
Małgorzata Tyszka-Czochara,,
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, Renata Francik
Renata Francik,,
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, Monika Marcinkowska
Monika Marcinkowska,,
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, Jakub Sikora (FoPaPE / IoAEaI)
Jakub Sikora,,
- Institute of Agricultural Engineering and Informatics
, Mateusz Malinowski (FoPaPE / IoAEaI)
Mateusz Malinowski,,
- Institute of Agricultural Engineering and Informatics
, Paweł Zagrodzki
Paweł Zagrodzki,,
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Journal seriesBiological Trace Element Research, ISSN 0163-4984, e-ISSN 1559-0720, (N/A 70 pkt)
Issue year2020
Vol193
No1
Pages204-213
Publication size in sheets0.5
Keywords in EnglishIodine deficiency, Brassica sprouts, Rutabaga, Thyroid gland, Immunology
ASJC Classification2700 General Medicine; 2704 Biochemistry, medical; 2712 Endocrinology, Diabetes and Metabolism; 1303 Biochemistry; 1308 Clinical Biochemistry; 1604 Inorganic Chemistry
DOIDOI:10.1007/s12011-019-01694-7
URL https://link.springer.com/content/pdf/10.1007%2Fs12011-019-01694-7.pdf
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
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Animals in Iodine Deficiency or Sulfadimethoxine Models of Thyroid Damage Are Differently Affected by the Consumption of Brassica Sprouts of 08-01-2020
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Score (nominal)70
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.882; WoS Impact Factor: 2018 = 2.431 (2) - 2018=2.406 (5)
Citation count*
Additional fields
FinansowanieThis study was supported by the following grants from the Polish Ministry of Science and Higher Education: K/DSC/000037, K/ZDS/001294, K/DSC/000805, K/DSC/001418, K/ZDS/005562.
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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