A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types

Tomasz Szmatoła , Artur Gurgul , Igor Jasielczuk , Tomasz Ząbek , Katarzyna Ropka-Molik , Zygmunt Litwińczuk , Monika Bugno-Poniewierska

Abstract

In the presented research, BovineSNP50 microarrays (Illumina) were applied to determine runs of homozygosity in the genomes of 11 cattle breeds maintained in Poland. These cattle breeds represent three basic utility types: milk, meat and dual purpose. Analysis of runs of homozygosity allowed the evaluation of the level of autozygosity within each breed in order to calculate the genomic inbreeding coefficient (FROH), as well as to identify regions of the genome with a high frequency of ROH occurrence, which may reflect traces of directional selectin left in their genomes. Visible differences in the length and distribution of runs of homozygosity in the genomes of the analyzed cattle breeds have been observed. The highest mean number and mean sums of lengths of runs of homozygosity were characteristic for Hereford cattle and intermediate for the Holstein-Friesian Black-and-White variety, Holstein-Friesian Red-and-White variety, Simmental, Limousin, Montbeliarde and Charolais breeds. However, lower values were observed for cattle of conserved breeds. Moreover, the selected livestock differed in the level of inbreeding estimated using the FROH coefficient. In regions of the genome with a high frequency of ROH occurrence, which may reflect the impact of directional selection, a number of genes were observed that can be potentially related to the production traits which are under selection pressure for specific production types. The most important detected genes were GHR, MSTN, DGAT1, FABP4, and TRH, with a known influence on the milk and meat traits of the studied cattle breeds.
Author Tomasz Szmatoła (VET)
Tomasz Szmatoła,,
- University Centre for Veterinary Medicine UJ-UR
, Artur Gurgul (VET)
Artur Gurgul,,
- University Centre for Veterinary Medicine UJ-UR
, Igor Jasielczuk (VET)
Igor Jasielczuk ,,
- University Centre for Veterinary Medicine UJ-UR
, Tomasz Ząbek
Tomasz Ząbek,,
-
, Katarzyna Ropka-Molik
Katarzyna Ropka-Molik,,
-
, Zygmunt Litwińczuk
Zygmunt Litwińczuk,,
-
, Monika Bugno-Poniewierska (FoAS / IoVS)
Monika Bugno-Poniewierska,,
- Institute of Veterinary Sciences
Journal seriesAnimals, ISSN 2076-2615, e-ISSN 2076-2615, (N/A 100 pkt)
Issue year2019
Vol9
No12
Pages1-24
Publication size in sheets1.15
Article number1024
Keywords in EnglishRuns of homozygosity; autozygosity; microarray; cattle
ASJC Classification3400 General Veterinary; 1103 Animal Science and Zoology
DOIDOI:10.3390/ani9121024
URL https://www.mdpi.com/2076-2615/9/12/1024/pdf
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
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A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types of 25-11-2019
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Score (nominal)100
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.148; WoS Impact Factor: 2018 = 1.832 (2)
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