The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction

Kinga Topolska , Marek Bieńko , Agnieszka Filipiak-Florkiewicz , Radosław Piotr Radzki , Ewa Cieślik

Abstract

Introduction. Osteoporosis, the “quiet epidemic”, is one of the most serious threats to public health. It is known that estrogen plays a significant role in the regulation of bone turnover, and its loss at menopause causes osteoporosis. Added to this, insufficient calcium intake accelerates bone mass loss, increasing the risk of fractures. Objective. The study aimed to answer the question whether a fructan-enriched diet could be helpful in preventing from disturbances in bone turnover caused by calcium restriction combined with ovariectomy-induced estrogen deficiency. The differences related to the kind of fructan and “matrix effect” of fructan action (form of addition) were also evaluated. Materials and method. The study was conducted using sham-operated (control groups) or ovariectomized (OVX) rats fed a calcium restricted diet. The treatment diets contained one of three fructan sources – Jerusalem artichoke, yacon and Beneo Orafti Synergy1 – added alone or as an ingredient of strawberry sorbet, all in the amount providing 8% fructans. Analyses of biological material included: serum Ca, Mg and P concentrations, alkaline phosphatase activity (ALP), osteocalcin (OC) and C-telopeptide degradation products from type I collagen (CTX). Densitometric parameters of femora were also assayed. Results. Among markers of bone turnover, the ALP activity depended both on the kind of fructan and the form of addition. The highest value was shown in the OVX group fed a low-calcium diet, whereas administration of diet enriched with Jerusalem artichoke led to an almost 50% decrease in the value of this parameter. Dietary fructans also lowered the OC level. Feeding rats with diet containing sorbet enriched in yacon or Jerusalem artichoke resulted in a decrease of CTX, compared to the diet containing yacon alone or fructan formulation in both forms No significant differences were observed in densitometric parameters between treatment groups. Conclusions. The obtained findings suggest that fructan administration with a calcium-restricted diet might exert a positive effect on bone turnover parameters. Regarding the form of their addition, it is possible that other constituents of sorbets contributed to the fructan action. It remains open whether this impact would be significant over a longer period of time.
Author Kinga Topolska (FoFT / Department of Plant Product Technology and Nutrition Hygiene)
Kinga Topolska,,
- Department of Plant Product Technology and Nutrition Hygiene
, Marek Bieńko - University of Life Sciences in Lublin
Marek Bieńko,,
-
, Agnieszka Filipiak-Florkiewicz (FoFT / Department of Plant Product Technology and Nutrition Hygiene)
Agnieszka Filipiak-Florkiewicz,,
- Department of Plant Product Technology and Nutrition Hygiene
, Radosław Piotr Radzki - University of Life Sciences in Lublin
Radosław Piotr Radzki,,
-
, Ewa Cieślik (FoFT / Department of Plant Product Technology and Nutrition Hygiene)
Ewa Cieślik,,
- Department of Plant Product Technology and Nutrition Hygiene
Journal seriesAnnals of Agricultural and Environmental Medicine, ISSN 1232-1966, e-ISSN 1898-2263, (N/A 70 pkt)
Issue year2020
Vol27
No2
Pages219-224
Publication size in sheets0.5
Keywords in Englishfructans, calcium dietary restriction, bone turnover, densitometry, ovariectomy
ASJC Classification2739 Public Health, Environmental and Occupational Health; 1105 Ecology, Evolution, Behavior and Systematics; 2311 Waste Management and Disposal
DOIDOI:10.26444/aaem/108658
URL http://www.aaem.pl/pdf-108658-52222?filename=The%20effect%20of.pdf
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa - Użycie Niekomercyjne (CC-BY-NC); after publication
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The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction of 24-07-2020
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Score (nominal)70
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.755; WoS Impact Factor: 2018 = 1.03 (2) - 2018=1.277 (5)
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FinansowanieThe study was founded by the National Science Centre Poland project, on the basis of Decision No. DEC-2011/01/B/ NZ9/03045.
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